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Ester-C Calcium Ascorbate is a unique and patented form of vitamin C. It is made using a proprietary, water-based manufacturing process which results in a pH neutral product that contains naturally occurring vitamin C metabolites. These metabolites activate the vitamin C molecules making it easier for the body to transport them from cell to cell for numerous health benefits.Ester-C stays in the body longer: A recent clinical study showed that Ester-C increased vitamin C levels in the body for up to 24 hours. White blood cell levels of Vitamin C were elevated in subjects receiving Ester-C when measured 24 hours after initial dose. The presence of key metabolites such as threonate has been shown to be responsible for this increased level and retention of Vitamin C by the cells. In a recently published study, individuals sensitive to acidic foods were given one gram of vitamin C as ascorbic acid or as Ester-C. Subjects reported heartburn "significantly more frequent and severe after intake of ascorbic acid" and subjects rated Ester-C as tolerated "very good" significantly more than ascorbic acid. So for anyone who has difficulty tolerating vitamin C, it's comforting to know that Ester-C is non-acidic and gentle on the stomach. The main benefit of Ester-C is its quick absorption and 24-hour retention in the immune system. Ester-C remains active in the white blood cells for up to 24 hours Ester-C offers powerful, highly advanced immune support Ester-C is non-acidic, so it's gentle on the digestive tract Ester-C contains naturally-occurring metabolites for quick absorption and maximum retention Ester-C is so unique it's patented Ester-C is backed by science.Studies have indicated that Ester-C is absorbed approximately twice as fast and efficiently, is transported into the cells about twice as fast and is retained in the body about twice as long as ordinary ascorbic acid.